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Hyodeoxycholic Acid (HDCA), also chemically designated as 3α,6α-dihydroxy-5β-cholan-24-oic acid, is a prominent secondary bile acid primarily derived from porcine bile metabolism. Unlike primary bile acids synthesized directly within hepatocytes, HDCA is formed through specific microbial biotransformations within the intestinal flora. In recent drug discovery paradigms, HDCA has emerged as a molecule of interest due to its unique target profile, acting on metabolic regulators such as the TGR5 receptor and the Farnesoid X Receptor (FXR).
For pharmaceutical formulators and chemical manufacturing organizations, acquiring consistent, high-purity HDCA is crucial. It serves as a precursor for the synthesis of advanced semi-synthetic bile acids, acts as an active pharmaceutical ingredient (API) for cardiovascular and hepatobiliary drug candidates, and serves as a vital surfactant in drug delivery systems. The clinical applications of HDCA focus on its ability to lower plasma cholesterol, inhibit gallstone formation, and mitigate chronic vascular inflammation.
| CAS Number | 83-49-8 |
| Molecular Formula | C24H40O4 |
| Molecular Weight | 392.57 g/mol |
| Melting Point | 200°C to 204°C |
| Appearance | White or almost white crystalline powder |
Established in 2012, Chengdu Chenlv Herb Co., Ltd. (referred to as "Chenlv Herb") has grown into a premier high-tech enterprise specializing in the R&D, production, and sales of high-purity botanical extracts, active pharmaceutical ingredients, and customized bile acids like HDCA.
Our mission is to deliver high-purity, highly active natural compounds to the pharmaceutical, health supplement, functional food, and cosmetic industries worldwide. Utilizing state-of-the-art separation and purification infrastructure, Chenlv Herb maintains rigorous quality controls that align with international monographs and standard operating procedures.
Why lead-tier biomedical and pharmaceutical brands choose Chenlv Herb as their strategic partner.
Leveraging deep chromatographic research to isolate and structuralize high-purity natural compounds matching strict client criteria.
Optimized industrial workflows ensuring rapid lead-time execution, eco-friendly extraction techniques, and structural stability.
Committed to green chemistry practices, minimizing wastewater footprint, and optimizing source material yields in compliance with environmental standards.
Dedicated technical support team providing comprehensive documentation package (COA, MSDS, GMP certificates, heavy metal test reports).
Equipped with analytical instruments (HPLC-ELSD, LC-MS, NMR, and ICP-MS) ensuring strict quality gates for raw and finished materials.
Over a decade of technical and regulatory expertise in natural plant active ingredients and bile acid derivatives.
Analyzing key market dynamics, procurement metrics, and strategic applications for international pharmaceutical supply chains.
In B2B sourcing pipelines, HDCA is categorized under critical starting materials or active pharmaceutical ingredients. Global buyers mandate strict compliance with impurities profiles, specifying limits on related substances (such as Cholic Acid, Deoxycholic Acid, and Chenodeoxycholic Acid). High-performance liquid chromatography (HPLC) coupled with Charged Aerosol Detection (CAD) or Evaporative Light Scattering Detection (ELSD) is standard practice for compound identification and purity verification.
Firms utilizing bile acid therapeutics face complex raw material sourcing issues, animal pathogens clearance (e.g., TSE/BSE risk management), and process scale-up bottlenecks. Chengdu Chenlv Herb resolves these problems by instituting fully auditable porcine source tracing, integrated virus inactivation validation protocols, and crystallization parameters optimized for micro-crystalline output consistency.
The manufacturing blueprint of HDCA is transitioning from simple acid-base precipitation toward hybrid biotransformation pathways. Genetic engineering of microbial host cells (such as optimized strains of Escherichia coli or Saccharomyces cerevisiae) allows biocatalytic 6α-hydroxylation of Lithocholic Acid (LCA) to yield highly purifiable bio-synthetic HDCA. Chengdu Chenlv Herb's R&D division actively maps out synthetic biology pathways to reduce dependency on animal raw materials, targeting a carbon-neutral and green-chemistry supply chain by 2027.
Due to its thermodynamic profile and high biocompatibility, Hyodeoxycholic Acid and natural extracts serve critical functions across diverse sectors.
Driven by the concept of "homology of medicine and food" and modern health needs, plant extracts and active bile elements have become core raw materials for natural supplements, lipid-modulating nutraceuticals, and metabolic enhancers.
From traditional clinical formulas to innovative modern therapeutics, bile acids and standardized active ingredients are critical for formulating treatments targeted at liver congestion, gallstone dissolution, and vascular endothelial protection.
With consumers demanding natural, safe, and biocompatible ingredients, surfactant active bile components and natural botanicals function as emulsifying agents, skin-soothing bio-compounds, and antioxidants.
Bile acid molecules act as performance enhancers in feed formulations, optimizing lipid absorption in young livestock, maintaining digestive system homeostasis, and upgrading overall feed conversion ratios (FCR).
Chenlv Herb provides one-stop contract manufacturing, synthesis optimization, and analytical testing services.
Initial technical consultation and formulation of specific compound purity, impurity tolerances, and physical powder parameters.
Providing a comprehensive commercial proposal detailing production schedules, transport tariffs, and volume-tiered prices.
Executing bilateral non-disclosure agreements, procurement contracts, and technical specification protocols.
Synthesizing pilot lab batches and sending them to the client for analytical validation and compatibility verification.
Upon sample validation, scaling operations within our GMP production floor with real-time process control metrics.
Performing analytical validation (HPLC-ELSD, heavy metals, residual solvents) and issuing the Certificate of Analysis (COA).
Packing under nitrogen protection and dispatching via controlled cold-chain logistics to international destinations.
Our quality system is verified by international regulatory frameworks to ensure pharmaceutical supply chain stability.
Read technical updates, production expansion milestones, and macro market reports from the plant extraction frontier.
With seasonal harvesting transitions shifting, raw material fluctuations affect the price trajectory of natural extracts. Dive into our analytical breakdown of supply and demand factors influencing costs.
As a leading platform for China's pharmaceutical industry on the global stage, we showcase our latest high-purity HDCA batches and standardized extract profiles at Booth C25.
Meet our leading chemical synthesis engineering experts, view analytical validation portfolios, and explore long-term supply agreement solutions for bile derivatives.
Technical guidance and answers to common industrial and chemical inquiries regarding HDCA.
Contact Chenlv Herb's application engineering division today to request analytical samples, verify pricing models, or discuss customized purification profiles.
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