Explore our premium grade plant extracts and synthetic compounds engineered for dynamic physiological applications.
An Industry Whitepaper on Sourcing, Semi-Synthesis, Micronization, and Therapeutic Advancements in Vascular Health.
Daflon, chemically represented as a Micronized Purified Flavonoid Fraction (MPFF), is the gold standard therapeutic agent for treating Chronic Venous Insufficiency (CVI), varicose veins, deep vein thrombosis, and acute hemorrhoidal attacks. MPFF traditionally consists of 90% Diosmin and 10% Hesperidin. Diosmin, a naturally occurring flavonoid glycoside, can be extracted from Citrus aurantium or derived synthetically via iodine-mediated oxidation of Hesperidin.
The critical differentiator in therapeutic efficacy is micronization. Standard Diosmin suffers from poor oral bioavailability due to large crystal aggregates that resist absorption in the gastrointestinal tract. By reducing the particle size to under 2 micrometers (D90 < 2μm), the surface area increases exponentially. This enhances dissolution velocity and intestinal absorption, thereby improving patient outcomes.
"The transition from generic coarse Diosmin to Micronized Purified Flavonoid Fraction represents a 400% increase in gastrointestinal absorption velocity, directly dictating clinical bio-equivalence to proprietary Daflon formulas."
To achieve premium-quality yet cheap Diosmin, manufacturers must optimize the conversion pathway. Our facility leverages a proprietary semi-synthesis route:
Chengdu Chenlv Herb Co., Ltd.
Chengdu ChenLv Herb Co.,Ltd. (referred to as "Chenlv Herb") was established in 2012 as a high-tech enterprise specializing in the R&D, production, and sales of botanical extracts and natural pharmaceutical ingredients. Committed to providing high-purity, highly active, and premium-quality natural raw materials, the company serves diverse industries, including pharmaceuticals, health supplements, food, and cosmetics.
Choose Chenlv Herb for products that deliver beyond expectations
Creative designs and tailored technical specifications that elevate your brand positioning in highly competitive target regions.
Eco-friendly packaging and optimized industrial production workflows aligned perfectly with contemporary international environmental standards.
End-to-end cosmetic and pharmaceutical packaging solutions integrated seamlessly with strict environmental regulatory oversight.
Rapid chemical analysis, dynamic logistics tracking, and accelerated project lifecycles to consistently meet your strict production schedules.
A dedicated QA and scientific validation team supporting and inspecting each chemical and botanical batch from harvest to cargo dispatch.
Decades of collective laboratory expertise ensuring flawless precision, international regulatory compliance, and consistent chemical stability.
Addressing the complex demands of modern supply chains, regulatory changes, and cost management.
Vascular protective agents represent a multi-billion dollar market globally, driven by aging populations, sedentary lifestyles, and rising awareness of vein diseases. Pharmaceutical buyers seek cost-effective yet reliable API (Active Pharmaceutical Ingredient) suppliers capable of providing consistent batch purity.
Historically, purchasing agents had to choose between high-cost Western European brand-name suppliers and cheap, inconsistent generic alternatives. Chenlv Herb resolves this trade-off. By leveraging advanced semi-synthesis technologies and high-efficiency purification steps in China, we deliver Diosmin that meets European Pharmacopoeia (EP) and United States Pharmacopeia (USP) standards at a fraction of the cost.
Furthermore, localized warehousing and support mean that global buyers receive customs clearance documentation, technical dossiers (DMF, CEP), and continuous quality assurance without time-zone or geographical barriers.
Chenlv Herb provides one-stop contract manufacturing services.
Determine product specifications and project requirements.
Provide a transparent proposal based on requirements.
Formalize the partnership and discuss manufacturing details.
Develop and optimize formulation samples.
Schedule order run within our GMP-certified facility.
Issue Certificates of Analysis verifying batch compliance.
Deliver safe, secure, and compliant products to your facility.
Natural raw materials adapted for medical, nutritional, and topical formulations
Driven by the concept of "homology of medicine and food" and modern health needs, plant extracts have gradually become the core raw materials for the development of health care products due to their natural, green and safe characteristics.
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From herbal formulas recorded in ancient books to modern innovative drugs, plant extracts occupy the prominent position in the pharmaceutical industry due to their natural active ingredients and unique pharmacological effects.
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With consumers' pursuit of natural, safe, and sustainable skincare concepts, plant extracts have become a new favorite in the cosmetics industry due to their mildness, versatility, and biocompatibility, bringing new solutions for skin care.
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Plant extracts have shown great potential in improving animal health, enhancing production performance and optimizing culture benefits, and are gradually becoming a research hotspot and new favorite in the field of animal nutrition.
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Our company is certified by ISO9001, ISO22000, HALAL, KOSHER and FDA etc.
Driving efficiency and green synthesis innovations for high-purity flavonoids.
The future of Daflon Diosmin production lies in reducing ecological footprints while increasing yield stability. The traditional synthesis of Diosmin involves heavy consumption of organic solvents. At Chenlv Herb, we are pioneering a shift toward biocatalytic processes, where engineered enzymes facilitate the conversion of Hesperidin to Diosmin in aqueous systems.
Additionally, our scientific roadmap focuses on next-generation particle size optimization, specifically examining the potential of nanoparticles to further enhance the dissolution rate. Our ongoing trials show that narrowing the particle size distribution (PSD) curve ensures uniform dosage uniformity in tablet and capsule formulations, helping our B2B partners minimize formulation failures.
Keeping you updated on market dynamics, natural product trends, and corporate exhibitions.
Recently, the market price of Citrus aurantium raw materials in China has been on the rise, drawing significant attention from the industry. As the new production season (May-June) comes to an end and new supplies gradually enter the market, price fluctuations have become a focal point due to supply and demand dynamics and cost considerations.
As a 'calling card' for leading China's pharmaceutical industry onto the global stage, the 23rd China Pharmaceutical Raw Materials Exhibition (CPHI China 2025) will join hands with the 18th China Pharmaceutical Machinery.
Join us at the upcoming API conference to discover new raw materials, negotiate bulk contract prices, and explore collaborative opportunities with our team.
Technical and procurement queries answered directly by our research and supply chain teams.
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