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In the global biochemical and pharmaceutical industry, understanding the strict molecular and regulatory parameters of Diosmin is critical for strategic sourcing. According to the National Institutes of Health (NIH) PubChem database, Diosmin is documented under PubChem CID 5281613. It is classified as a naturally occurring flavonoid glycoside, molecularly formulated as C28H32O15, and systematically recognized by its IUPAC name: 7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one.
| Property / Parameter | PubChem & Official Specification Data | Industrial Sourcing Relevance |
|---|---|---|
| CAS Registry Number | 520-27-4 | Standardized identifier for customs clearance and global logistics. |
| PubChem Compound ID | CID 5281613 | Cross-verified database for pharmacological and safety profiling. |
| Molecular Weight | 608.5 g/mol | Crucial for stoichiometric calculations and bioavailability assessments. |
| Origin Specification | Semisynthetically derived from Hesperidin (extracted from immature Citrus aurantium L. fruits) | Ensures sustainability and compliance with clean label/natural source guidelines. |
| Standard Particle Size | Micronized (d90 < 2μm or < 5μm options) | Determines absorption rate and bioavailability index in formulations. |
Diosmin acts as a highly effective phlebotonic and vascular protector. It works by prolonging the vasoconstrictor effect of norepinephrine on the venous wall, thereby increasing venous tone and reducing venous capacitance, distensibility, and stasis. By targeting key microcirculatory pathways, it lowers capillary hyperpermeability and boosts lymphatic drainage. In clinical applications, it is the primary active ingredient for treating Chronic Venous Insufficiency (CVI), varicose veins, deep vein thrombosis (DVT), and acute hemorrhoidal attacks.
Established in 2012, Chengdu Chenlv Herb Co., Ltd. (referred to as "Chenlv Herb") operates as a premier high-tech enterprise specializing in the research and development, large-scale production, and global sales of premium botanical extracts and natural active pharmaceutical ingredients (APIs).
Committed to providing high-purity, highly active, and premium-quality natural raw materials, the company serves diverse industries, including pharmaceuticals, health supplements, functional food, animal nutrition, and cosmetics. By pairing state-of-the-art purification technology with a sustainable supply chain, we deliver custom-fit, high-performance ingredients that comply with international regulatory monographs.
READ MOREOver a decade of scaling biotechnology research, serving global pharmaceutical brand owners and ingredient distributors with validated, batch-to-batch consistency.
For international sourcing directors, partnering with a Chinese Diosmin factory provides unmatched strategic advantages across the supply chain, cost control, and quality systems. China has established the world’s most robust raw material ecosystem for flavonoid synthesis, particularly starting with Citrus aurantium.
China is home to the largest cultivations of Citrus aurantium L. (Bitter Orange), the primary botanical source of Hesperidin. Having direct access to local agricultural resources eliminates international logistics risks and ensures a steady supply of high-grade raw materials.
Standard Diosmin has poor water solubility and low bioavailability. Chinese factories have pioneered industrial-scale air-jet micronization systems. This technology refines the particle size distribution to a d90 < 2 micrometers, significantly improving absorption rates in human clinical studies.
Transitioning Hesperidin to Diosmin requires highly controlled dehydrogenation and purification steps. Our production lines feature complete vertical integration. This setup keeps manufacturing efficient, cuts down on solvent waste, and maintains competitive pricing.
China’s top-tier manufacturers align their facilities with GMP, ISO9001, ISO22000, Halal, Kosher, and FDA regulations. We support our global partners by providing comprehensive regulatory documentation, including DMF, CoA, and technical dossiers.
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Our Diosmin solutions are designed to fit diverse formulations in the global market. Because the compound is naturally poorly absorbed, our team focuses on improving formulation stability, increasing absorption, and enhancing active delivery across both systemic and topical systems.
Typically formulated as a 90:10 ratio of Diosmin to Hesperidin. Our MPFF blends meet EP monograph standards and are widely used in oral tablets and capsules. They target deep chronic venous disorders by protecting venous valves and strengthening capillary integrity.
Incorporated into modern skincare creams, gels, and serums. It helps reduce puffiness under the eyes, lightens dark circles, and calms facial redness by supporting local microcirculation and soothing capillary inflammation.
Used in animal feed formulations to support healthy circulation and vascular integrity in livestock. It helps improve overall vitality and supports physiological balance under stress conditions.
Providing high-purity natural raw materials for diverse target industries
Driven by the concept of "homology of medicine and food" and modern health needs, plant extracts have gradually become the core raw materials for the development of health care products due to their natural, green and safe characteristics.
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From herbal formulas recorded in ancient books to modern innovative drugs, plant extracts occupy the prominent position in the pharmaceutical industry due to their natural active ingredients and unique pharmacological effects.
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With consumers' pursuit of natural, safe, and sustainable skincare concepts, plant extracts have become a new favorite in the cosmetics industry due to their mildness, versatility, and biocompatibility, bringing new solutions for skin care.
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Plant extracts have shown great potential in improving animal health, enhancing production performance and optimizing culture benefits, and are gradually becoming a research hotspot and new favorite in the field of animal nutrition.
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Sourcing pharmaceutical-grade Diosmin requires a strict, step-by-step evaluation of chemical assays, residual solvents, and regulatory certificates. Global brands should evaluate prospective factories against this framework to ensure regulatory alignment and product safety:
| Evaluation Parameter | Acceptable Range (USP/EP Standards) | Chenlv Herb Factory Standard Compliance |
|---|---|---|
| HPLC Assay (Diosmin) | 90.0% to 102.0% (on anhydrous basis) | Minimally 95.0% - 98.5% (High HPLC Purity) |
| Related Substances (Linarin, Hesperidin) | Hesperidin ≤ 4.0%; Linarin ≤ 3.0% | Fully controlled and tested via calibrated HPLC detectors |
| Heavy Metals (Pb, As, Cd, Hg) | ≤ 10 ppm total limit | Strictly controlled via ICP-MS analysis (limit ≤ 1.0 ppm) |
| Loss on Drying | ≤ 6.0% | Maintained ≤ 4.0% for enhanced formulation shelf life |
| Solvent Residues (Ethanol, Dichloromethane) | Within ICH limits (e.g., Ethanol ≤ 5000 ppm) | Strictly monitored; dichloromethane and benzene-free options available |
To ensure smooth regulatory approval, our quality management systems are designed to simplify compliance processes. We provide clear documentation, including DMF registration documents, complete stability reports, and analytical validation methods. This supporting paperwork helps minimize time-to-market delays for new product launches.
Chenlv Herb provides one-stop contract manufacturing services.
Communicate with customers to determine product requirements
Provide a proposal quotation based on customer requirements
Sign a contract to further discuss the details of cooperation
Make samples for product trial and testing
After customers confirm the samples, the factory schedules the production order
The factory tests the products and issues a certificate of analysis
Deliver finished products to customers
Our company is certified by ISO9001, ISO22000, HALAL, KOSHER and FDA etc.
For inquiries about our products or price list, please leave your email to us and we will be in touch within 24 hours.
We integrated research and development, manufacturing, and sales together.
Recently, the market price of Citrus aurantium raw materials in China has been on the rise, drawing significant attention from the industry. As the new production season (May-June) comes to an end and new supplies gradually enter the market, price fluctuations have become a focal point due to supply and demand dynamics and cost considerations.
READ MOREAs a 'calling card' for leading China's pharmaceutical industry onto the global stage, the 23rd China Pharmaceutical Raw Materials Exhibition (CPHI China 2025) will join hands with the 18th China Pharmaceutical Machinery.
READ MOREPartnering with domestic and international researchers, Chenlv Herb steps forward to showcase its customized plant extraction methods and high-purity APIs at leading regional conferences.
READ MOREExpert answers regarding PubChem data, chemical structures, and procurement procedures
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