Direct supply from Chengdu Chenlv Herb's state-of-the-art facilities
In the field of cellular gerontology and metabolic optimization, the combination of Nicotinamide Riboside (NR) and Pterostilbene represents a premier class of longevity supplements. Nicotinamide Riboside acts as a highly efficient precursor to Nicotinamide Adenine Dinucleotide (NAD+), a vital coenzyme present in all living cells that is essential for cellular respiration, DNA repair, and mitochondrial bioenergetics. As biological organisms age, intracellular NAD+ levels drop significantly, leading to mitochondrial decay, decreased cellular energy production, and age-related functional decline.
Pterostilbene, a naturally occurring dimethylated analogue of resveratrol, is a potent polyphenol predominantly found in blueberries and grapevine leaves. Due to its unique chemical structure—specifically, its two methoxy groups—pterostilbene exhibits far greater lipophilicity, oral bioavailability, and cellular uptake compared to resveratrol. Pterostilbene works primarily as an activator of Sirtuins (specifically SIRT1), a family of NAD+-dependent deacetylases that regulate cellular health pathways, chromatin structure, and stress response mechanisms.
When administered together, NR and Pterostilbene function in a potent synergistic loop: NR replenishes the intracellular pool of NAD+ required by Sirtuins, while Pterostilbene upregulates SIRT1 catalytic activity. This dual action enhances mitochondrial biogenesis, maintains telomere integrity, regulates circadian rhythms, and modulates inflammatory signaling pathways, making it a highly sought-after formulation for the dietary supplement, functional food, and pharmaceutical industries.
The global longevity market is undergoing a major structural shift. Consumer demand has evolved from superficial, topical beauty products toward scientifically validated, intracellular anti-aging interventions. The wellness market, now driven by preventative healthcare and longevity therapies, is experiencing a compound annual growth rate (CAGR) of over 12% in the premium active ingredients segment. In particular, NAD+ precursors like NR, NMN, and Sirtuin activators like Pterostilbene have emerged as the fastest-growing categories in North America, Europe, and East Asia.
B2B procurement trends show that brand owners are increasingly demanding combination formulas rather than single-ingredient supplements. Formulating NR alongside Pterostilbene allows brands to stand out in a competitive market by offering scientifically supported synergistic benefits. Furthermore, there is a clear trend toward green chemistry and bio-fermentation methods in manufacturing. Buyers are looking for suppliers who can guarantee sustainably sourced, solvent-free, and high-purity active compounds that comply with international environmental, health, and safety regulations.
For global pharmaceutical brands and supplement manufacturers, securing a reliable, consistent, and cost-effective supply of NR and Pterostilbene is a major supply chain challenge. In our work with international purchasing managers, we have identified several critical requirements for global raw material procurement:
As a leading supplier in the botanical and biochemical extract sector, Chengdu Chenlv Herb addresses these challenges with integrated macro-level solutions. We bridge the gap between scientific innovation and industrial-scale manufacturing. Our R&D team works continuously to refine the crystallization processes of Nicotinamide Riboside and the green chemical synthesis pathways of high-purity Pterostilbene.
By optimizing enzymatic synthesis routes, we have reduced waste by-products and lowered overall manufacturing costs, allowing us to pass significant volume discounts to our global partners. Additionally, we provide customized formulation services. This includes co-crystals, micro-encapsulation to protect hygroscopic compounds, and ready-to-fill powder blends designed to optimize downstream manufacturing efficiency, whether for capsule filling, tableting, or ready-to-mix sachets.
Chengdu ChenLv Herb Co.,Ltd. (referred to as "Chenlv Herb") was established in 2012 as a high-tech enterprise specializing in the R&D, production, and sales of botanical extracts and natural pharmaceutical ingredients. Committed to providing high-purity, highly active, and premium-quality natural raw materials, the company serves diverse industries, including pharmaceuticals, health supplements, food, and cosmetics.
Headquartered in the southwest bio-industry corridor in Chengdu, China, we leverage rich local botanical resources and combine them with advanced extraction, isolation, and purification technologies to deliver reliable ingredients that consistently exceed client expectations.
READ MORE ABOUT USWhy global industry leaders choose Chenlv Herb as their primary raw materials partner
Our dedicated laboratory continuously optimizes crystallization processes and synthetic pathways to enhance biological activity and raw material stability.
Optimized manufacturing lines and structured logistics allow us to maintain excellent response times, keeping your production schedules running smoothly.
We are committed to reducing environmental impact through eco-friendly solvent recycling systems and bio-catalysis manufacturing processes.
From custom sample formulation to custom export documentation and regulatory clearance support, we assist you at every stage of the procurement cycle.
Each batch of raw material undergoes thorough testing by third-party laboratories. Every order is shipped with a comprehensive Certificate of Analysis (CoA).
With years of export experience to regions including North America, the European Union, and South Asia, we ensure smooth and fully compliant international trade.
Extending active ingredient technologies across key vertical markets
Driven by preventative health trends and modern clinical research, our high-purity longevity compounds serve as the foundation for innovative dietary supplements.
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Providing high-purity active pharmaceutical ingredients (APIs) and botanical intermediates that meet strict compliance and pharmacopoeia standards.
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Integrating advanced antioxidants into skincare formulations to shield the skin barrier, neutralize free radicals, and support skin regeneration.
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Optimizing animal feed supplements with natural bioactive molecules to support immunity, metabolic health, and general wellness.
Read More ➔One-stop contract manufacturing and supply chain solutions tailored to your brand's specifications
Understanding your project specifications, purity needs, and regulatory targets.
Providing transparent, tiered volume quotes and sample availability timelines.
Establishing purchase agreements, quality standards, and intellectual property rights protection.
Synthesizing and delivering test samples for your internal testing and formulation trials.
Scheduling scale-up production in our GMP-compliant facilities.
Performing HPLC, heavy metal, and microbiological testing on the finished batch.
Arranging temperature-controlled shipping with complete export and import documentation.
Our facilities and products are fully certified by leading international compliance bodies
Entering international longevity markets requires deep regulatory compliance. At Chengdu Chenlv Herb, we assist our partners with complete documentation. This includes DMFs (Drug Master Files), EDMFs, and full technical dossiers to support compliance with international agencies like the FDA, EFSA, and regional health authorities. Our regulatory team keeps pace with updates to the US Dietary Supplement Health and Education Act (DSHEA), European Novel Food Regulations, and strict quality directives in the Asia-Pacific region.
In addition to documentation, our local support networks in key markets provide real-time assistance. We coordinate with local agents to ensure raw material deliveries meet regional standards. This includes Kosher and Halal dietary certifications, custom analytical verification (such as NMR and LC-MS), and standardizing allergen-free profiles, ensuring a smooth transition through customs and straight to your packaging lines.
Our research roadmap for the next decade is focused on improving stability and bioavailability. A primary challenge with Nicotinamide Riboside is its vulnerability to moisture and enzymatic degradation in the digestive tract. Chenlv Herb is currently testing next-generation delivery platforms, including liposomal delivery systems and co-crystal formulations with pterostilbene. These technologies protect the active molecules, allowing for slower release and higher overall absorption.
In our synthesis systems, we are moving toward biocatalysis and enzymatic synthesis routes. This transition lowers our energy footprint and decreases manufacturing waste, aligning our processes with global green manufacturing standards. Through these technological steps, we aim to continue lowering production costs, helping us supply top-tier raw materials to global buyers at competitive prices.
Professional answers to common technical, logistics, and quality questions
Stay informed on the latest plant extraction technologies and biochemical trends
Recently, the market price of Citrus aurantium raw materials in China has risen, drawing industry attention. As the production season ends, supply and demand dynamics continue to drive market pricing.
As a key event for China's pharmaceutical industry, the 23rd CPHI China 2025 will connect leading manufacturers, researchers, and global buyers to discuss next-generation ingredients.
We are showcasing our latest enzymatic synthesis developments and high-purity longevity ingredients at the upcoming API conference. Meet our formulation experts at our booth.
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