Sinefrina (Synephrine), specifically p-synephrine, is a naturally occurring alkaloid primarily extracted from the immature dried fruit of Citrus aurantium (Bitter Orange). In the global nutraceutical, sport nutrition, and weight-management sectors, Synephrine has solidified its role as a premier active compound for metabolic acceleration, thermogenesis, and clean energy formulation.
As regulatory bodies worldwide place more scrutiny on synthetic stimulants, the demand for standardized, plant-derived extracts containing 6% to 98% HPLC Sinefrina has scaled exponentially. Market indicators predict a steady CAGR in the global supply of Citrus aurantium extracts, driven heavily by applications in weight management and sports science. Our ODM and OEM production lines address these needs directly, offering customized purity levels tailored to specific regional regulatory standards.
Why Chengdu Chenlv Herb stands out as the premier industrial hub for botanical extraction
We combine advanced extraction methodologies with chromatographic isolation systems to elevate target ingredient potency while eliminating unwanted byproducts.
Operating a continuous countercurrent extraction system ensures high efficiency and cost savings, allowing us to offer highly competitive pricing structures.
Our raw material integration model links green farming initiatives in China directly with factory logistics, minimizing carbon footprint and raw material loss.
Our global operations department works closely with distribution channels in Europe, Asia, and North America, offering rapid lead times and custom packaging options.
Equipped with modern testing facilities (HPLC, GC, AAS), we issue batch-specific Certificates of Analysis (COA) to guarantee stability, safety, and regulatory compliance.
With years of experience in the extraction and export sectors, we offer valuable regulatory support for customs clearance and raw material homologation.
Chengdu ChenLv Herb Co.,Ltd. is a modern high-tech enterprise specializing in the R&D, production, and sales of botanical extracts and natural active pharmaceutical ingredients. Our primary mission is to supply high-purity, highly active, and clean-label natural ingredients to global partners across the dietary supplement, functional food, cosmetic, and animal nutrition sectors.
Formulating high-impact products with standardized Citrus Aurantium Extracts
Synephrine is a core ingredient in weight-management capsules, fat-burning formulas, and metabolic boosters, utilizing natural active compounds to help optimize energy expenditure.
Leveraged in therapeutic formulations aiming to support cardiovascular response, bronchial relaxation, and circulation improvement under careful medical formulations.
Utilized in topical body-shaping creams and anti-cellulite formulations, Synephrine helps promote microcirculation and fatty acid mobilization in dermal layers.
Synephrine functions as a natural metabolic regulator in feed additives, helping optimize feed conversion ratios, promote growth performance, and support immune responses.
Actual pricing depends on volume, purity requirements, and customizable packaging parameters.
| Active Ingredient | Purity/Specification | Test Method | Reference Price (USD/kg) | MoQ Requirement | Packaging Options |
|---|---|---|---|---|---|
| p-Synephrine (Sinefrina) | 6% Standardized Extract | HPLC | $12.50 - $18.00 | 25 kg (1 Drum) | Double PE bag inside, fiber drum outside |
| p-Synephrine (Sinefrina) | 10% Standardized Extract | HPLC | $19.00 - $25.00 | 25 kg (1 Drum) | Custom labeling available |
| p-Synephrine (Sinefrina) | 30% Concentrated Extract | HPLC | $35.00 - $48.00 | 25 kg | Nitrogen flushed drums |
| p-Synephrine Hydrochloride | 98% High Purity Powder | HPLC / Titration | $75.00 - $98.00 | 10 kg | Mylar foil bags / Custom drums |
| Synephrine Tartrate | 98% Pharma Grade | HPLC | Inquire Direct | 10 kg | GMP compliant secondary packing |
* Note: The prices listed above represent reference ranges for bulk wholesale purchases. Contact our sales department for a customized quotation.
Our 7-step turnkey manufacturing pathway ensures quality assurance and rapid order execution.
Initial consult to specify analytical profiles, dosage forms, packaging requirements, and compliance standards.
Detailed cost breakdown based on purity specifications, raw material yield, logistics, and target pricing.
Establishing binding contracts with guaranteed lead times, quality limits, and intellectual property terms.
Our lab develops customized test batches for validation and analytical verification by your internal QC teams.
Upon sample sign-off, raw materials are processed through our high-capacity commercial extraction lines.
Our quality department runs final assay tests, heavy metal screens, and microbiology tests before releasing COAs.
Secured freight loading and logistics support, ensuring customs clearance documents reach your port of entry smoothly.
We adhere to global standards to guarantee product safety and purity.
In industrial-scale botany, isolating p-synephrine requires meticulous environmental controls and precise chemical extraction steps. Bitter orange peel contains a matrix of protoalkaloids (including p-synephrine, hordenine, octopamine, and tyramine). Standardizing the extract to isolate target active molecules requires specialized resin column chromatography and purification steps.
At Chengdu Chenlv Herb, our purification line uses macroporous adsorption resins. The Citrus Aurantium biomass undergoes hydro-alcoholic extraction, concentrating the primary active compounds. Elution flow rates, solvent concentration ratios, and temperature ranges are monitored via SCADA control loops to prevent the degradation of heat-sensitive compounds. This allows us to offer customized purity specifications that match our customers' exact formulation requirements.
A primary concern for brands selling dietary supplements globally is the presence of undesirable compounds like octopamine. Many regulatory authorities restrict octopamine levels in food supplements due to its potential cardiovascular effects. Our extraction processes are engineered to selectively partition p-synephrine, keeping residual octopamine below detectable limits to comply with strict European food standards.
Raw material yields fluctuate based on seasonal conditions during the harvest months of May and June. During these periods, early fruit size and climate patterns influence alkaloid content. Establishing long-term raw material agreements with growers helps buffer production lines against sudden market spikes, allowing us to maintain stable wholesale pricing for our partners.
From a formulation perspective, Synephrine is often combined with other natural compounds to support energy expenditure and metabolic rate. In pre-workout formulations, it is frequently blended with green tea catechins (EGCG) and caffeine to target energy pathways. Our custom blending and granulation options simplify these formulations, supplying ready-to-fill granulated powders designed for high-speed capsule machines.
Essential insights for procurement managers, distributors, and formulation chemists.
The bulk price of Synephrine (Sinefrina Pret) depends on three main factors:
Our extraction lines utilize proprietary macroporous resin adsorption chromatography. This technology separates p-synephrine from octopamine, tyramine, and other trace alkaloids based on molecular size and polarity. This process ensures our high-purity Synephrine meets global anti-doping and sports organization guidelines.
p-Synephrine Free Base is the natural alkaloid in its un-ionized form, commonly used in dietary supplement formulations where direct blending occurs. p-Synephrine Hydrochloride (HCl) is the salt form, which offers greater water solubility and stability. Synephrine HCl is often preferred for liquid formulations, effervescent powders, and specific pharmaceutical applications.
Our facilities are fully certified under ISO9001 (Quality Management), ISO22000 (Food Safety), HACCP, KOSHER, HALAL, and registered with the US FDA. We guarantee trace accountability from raw Citrus aurantium harvest to the final batch shipment.
Yes. We offer customizable packaging solutions for bulk quantities, ranging from 1 kg vacuum-sealed bags to 25 kg fiber drums. We can customize labeling with custom batch numbering, customer-specified product names, and multi-language SDS/safety documentation to assist with customs clearance.
Standard spot stock orders are shipped from our warehouse within 3 to 5 business days. Custom ODM extractions, special granulometry requests, or custom bulk packaging orders typically take 15 to 25 business days, depending on material sourcing and QA verification protocols.
Follow our exhibition calendar and agricultural crop updates
Recent market price trends for Citrus aurantium raw materials in China show upward pressure due to seasonal harvest patterns. Sourcing early during the May-June harvest period helps secure stable costs for bulk production runs.
Chengdu Chenlv Herb invites global partners to connect with us at the 23rd China Pharmaceutical Raw Materials Exhibition (CPHI China 2025) in Shanghai to explore new botanical extraction technologies.
We invite you to join us at the 92nd API China conference. Visit our booth to discuss bulk API sourcing, custom synthesis options, and trace quality protocols.
For inquiries regarding our active ingredients, custom specifications, or a tailored quotation, submit your email address. Our sales representatives will respond within 24 hours.
