Licochalcone A is a bioactive retrochalcone isolated from the roots of licorice plants, primarily Glycyrrhiza inflata. Revered in clinical dermatology and advanced pharmacology, Licochalcone A exhibits potent anti-inflammatory, anti-oxidant, anti-microbial, and skin-soothing properties. Unlike standard glycyrrhizin derivatives, Licochalcone A acts specifically on target molecular pathways to reduce sebum production, suppress inflammatory cascades (such as NF-κB activation), and inhibit the proliferation of Cutibacterium acnes.
For global cosmetics formulating teams and pharmaceutical product developers, sourcing verified OEM Licochalcone A with exact purity levels is paramount. Chengdu Chenlv Herb Co., Ltd. provides scale-up manufacture, standardizations (from 1% cosmetic dilutions to 98% pure HPLC standards), and global regulatory documentation.
| Property / Specification | Details & Standards |
|---|---|
| Common Name | Licochalcone A (Licorice Chalcone A) |
| Botanical Source | Glycyrrhiza inflata Root |
| CAS Number | 58749-22-7 |
| Chemical Formula | C21H22O4 |
| Available Grades | 1% - 5% Cosmetic liquid, 10% - 98% Powder (High Purity HPLC) |
| Primary Target Pathways | NF-κB Inhibition, Tyrosinase suppression, Sebum-lipid downregulation |
Chengdu Chenlv Herb Co., Ltd. (referred to as "Chenlv Herb") was established in 2012 as a high-tech enterprise specializing in the research, development, production, and sales of botanical extracts and natural pharmaceutical ingredients. Committed to providing high-purity, highly active, and premium-quality natural raw materials, the company serves diverse industries, including pharmaceuticals, health supplements, food, and cosmetics.
By utilizing our geographical proximity to the rich botanical corridors of Western China, we source the highest grade Glycyrrhiza inflata crops. Our processing facility incorporates advanced chromatography systems, ensuring that our active molecules like Licochalcone A are extracted with minimized ecological impact and zero chemical residue.
Established In Chengdu, China
Over a decade of scaling biotechnology research into commercialized, high-purity botanical raw material supplies for domestic and global markets.
We integrate upstream cultivation control with advanced downstream purification technologies to guarantee standard-setting chemical profiles.
Creative formulation designs and custom specifications that elevate your brand and guarantee optimal skin penetration.
Eco-friendly packaging and closed-loop extraction parameters aligned with modern sustainable values.
End-to-end green manufacturing processes that protect natural resources while maximizing compound yield.
Fast production turnaround and flexible logistic pipelines to match your strict product launch timelines.
State-of-the-art analytical testing (HPLC, GC, MS) with third-party verification for every batch.
Decades of combined biotechnology experience ensuring precision, reproducibility, and industrial-scale reliability.
From soothing inflammatory dermatoses to fortifying livestock health, our customized Licochalcone A fractions serve as high-potency functional agents across four major global sectors.
Driven by the concept of "homology of medicine and food", Licochalcone A acts as a potent adaptogen, safeguarding gastrointestinal linings and boosting cardiovascular cellular defense.
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Incorporate high-purity (98% HPLC) Licochalcone A into therapeutic formulas for acute eczema, rosacea, and cellular anti-proliferative research targeting oncology profiles.
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The gold standard for calming sensitive skin. Effectively regulates sebum, eliminates stubborn acne, suppresses UV-induced free radicals, and lightens post-inflammatory hyperpigmentation.
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A natural alternative to synthetic growth promoters, our agricultural grade Licochalcone fractions enhance gut immunity, control inflammation, and elevate feed absorption ratios.
Read MoreFrom initial molecule design and target purity profiling to mass production runs, we provide a streamlined, transparent workflow.
Initial technical consultation to establish targets: target purity levels, batch sizing, vehicle compatibilities, and carrier choices.
Detailed cost breakdown sheets, transparent packaging options, regulatory filing inclusions, and freight timelines.
Formalizing partnership agreements, NDAs, analytical methodologies, standard operating procedures, and product specifications.
Synthesizing pilot batches of Licochalcone A tailored to your formulation metrics. Samples are shipped for physical and chemical evaluation.
Upon sample sign-off, our GMP-compliant plant initiates large-scale extraction utilizing automated solvent-recycle systems.
Rigorous laboratory testing of the finished batch. Issuance of HPLC chromatograms, heavy metals checks, and microbiological assays.
Secure packing using nitrogen flushing and thermal barriers. Door-to-door delivery with customs clearance assistance.
Our raw materials satisfy the regulatory guidelines of major global markets. Chenlv Herb products are certified by ISO9001, ISO22000, HALAL, KOSHER, and FDA.
China's Xinjiang and Gansu provinces contain the world's most extensive, ecologically rich growing environments for wild and cultivated Glycyrrhiza inflata. Because we are based in Chengdu, Chenlv Herb possesses a logistics pipeline directly connected to these major licorice crop fields. Our supply model mitigates geopolitical trade shifts, stabilizes raw plant costs, and guarantees uninterrupted supplies to global brands year-round.
Conventional organic solvent extractions often result in trace solvent retention and reduce the natural biological activity of heat-sensitive chalconoids. Chenlv Herb is piloting advanced green chemistry systems utilizing Supercritical CO₂ combined with food-grade ethanol co-solvents. This process keeps extraction temperatures low, prevents the degradation of Licochalcone A, and achieves an eco-friendly end product with 99% recycled gas efficiency.
As a lipophilic molecule, Licochalcone A can present formulation challenges in water-based cosmetic serums. Our R&D department offers micro-encapsulation services using natural lipid nanoparticles (SLNs) and cyclodextrin complexes. These modifications increase water solubility, improve light stability, and support controlled release profiles in topical skin systems.
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As a leading name in botanical extractions, Chengdu Chenlv Herb invites global industry professionals to discuss natural active ingredient innovations at the upcoming 23rd CPHI China 2025.
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Chenlv Herb continues to expand its cooperative networks. Our technical sales team is presenting our updated high-purity Licochalcone A and active licorice fractions at this premier pharmaceutical ingredients event.
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