Premium phytomedicines and biopharmaceutical compounds optimized for low-density lipoprotein (LDL) receptor pathway enhancement and systemic lipid regulation.
Scientific perspectives on molecular mechanisms driving plant-derived lipid reduction and clearance optimization.
Low-Density Lipoprotein (LDL) metabolism is heavily dependent on hepatic LDL receptor (LDLR) density and cellular internalization capability. Modulating these pathways using plant extracts—specifically isoquinoline alkaloids like Berberine Hydrochloride and bioflavonoids such as Rutin and Diosmin—has become a cornerstone of preventative medicine and cardiometabolic therapy. By inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9), active ingredients boost hepatic LDLR expression, accelerating clearance of atherogenic particles from the circulation.
Additionally, physiological mechanisms such as bile acid synthesis regulation driven by bile acids (like Deoxycholic Acid and Sodium Tauroursodeoxycholate) play critical roles in clearing peripheral cholesterol. These bile acids stimulate farnesoid X receptors (FXR) and G-protein coupled bile acid receptors (TGR5), which direct hepatic metabolism towards converting cholesterol into bile salts, thus lowering circulating LDL-c. Our deep expertise in manufacturing high-purity extraction materials guarantees target therapeutic active levels across all customized batches.
Chengdu ChenLv Herb Co.,Ltd. (referred to as "Chenlv Herb") was established in 2012 as a high-tech enterprise specializing in the R&D, production, and sales of botanical extracts and natural pharmaceutical ingredients.
Committed to providing high-purity, highly active, and premium-quality natural raw materials, the company serves diverse industries, including pharmaceuticals, health supplements, food, and cosmetics. Driven by clinical research and process engineering innovation, we operate state-of-the-art facilities capable of meeting strict multinational regulatory audits.
Unlocking efficiency, stability, and scale through Chengdu's prime botanical access and industrialized production technology.
Located in Chengdu, Sichuan Basin, Chenlv Herb accesses one of China's most diverse ecological zones for wild and cultivated medicinal herbs. This eliminates long-distance transport costs for raw resources (e.g., Honeysuckle, Ginkgo Biloba, Citrus aurantium) and preserves volatile active compounds during harvest-to-processing cycles.
Our 2,711㎡ facility utilizes modern multi-stage extraction columns, counter-current extraction systems, and low-temperature vacuum evaporation technologies. These innovations maximize recovery of target bio-molecules like Berberine HCl and Diosmin while maintaining low energy and carbon footprints.
From raw agricultural sourcing to final micronized powders, we control every single link in the supply chain, stabilizing wholesale pricing against global inflation.
Integrated chromatography lines ensure all active compounds pass stringent EU/USP standards regarding chemical residues and heavy metals.
Benefit from our close proximity to international railway networks (Chengdu-Europe Express) and air freight hubs, offering rapid, low-carbon transit.
Choose Chenlv Herb for products that deliver beyond expectations.
Creative designs that elevate your brand and optimize bioavailability of lipid-regulating products.
Eco-friendly packaging aligned with today's values and energy-efficient isolation processes.
End-to-end cosmetic packaging solutions and green agricultural raw sourcing.
Fast turnaround to meet your timelines with reliable support at every step of global logistics.
A dedicated team supporting you every step of the way, verifying batch parameters via HPLC/GC-MS.
Years of expertise ensuring precision and excellence, delivering raw substances compliant with USP and EP monographs.
Adapting natural lipid-targeting science for diverse sectors—from clinical formulas to functional nutrition.
Driven by the concept of "homology of medicine and food" and modern health needs, plant extracts have gradually become the core raw materials for the development of health care products due to their natural, green and safe characteristics.
Local Scenario: Upregulation of hepatic LDL-c clearance via dietary supplements designed to lower hypercholesterolemia risks in aging demographics.
From herbal formulas recorded in ancient books to modern innovative drugs, plant extracts occupy the prominent position in the pharmaceutical industry due to their natural active ingredients and unique pharmacological effects.
Local Scenario: Active pharmaceutical ingredients (APIs) targeting hypercholesterolemia, venous insufficiency, and cellular microcirculation pathways.
With consumers' pursuit of natural, safe, and sustainable skincare concepts, plant extracts have become a new favorite in the cosmetics industry due to their mildness, versatility, and biocompatibility, bringing new solutions for skin care.
Local Scenario: Lipid barrier protection, anti-inflammatory capillary support, and localized cell-growth stimulation via Ergothioneine-enriched cosmetics.
Plant extracts have shown great potential in improving animal health, enhancing production performance and optimizing culture benefits, and are gradually becoming a research hotspot and new favorite in the field of animal nutrition.
Local Scenario: Regulating dietary fatty acid absorption and preventing hepatic lipidosis in high-yield livestock and domestic companion animals.
Addressing B2B purchasing demands, structural regulatory files, and quality thresholds for key international markets.
For procurement officers in multinational pharmaceutical, functional food, and cosmetic corporations, purchasing phytochemicals involves navigating strict quality control parameters. Active components like Diosmin, Hidrosmin, and Sodium Tauroursodeoxycholate require rigorous analytical validation—including HPLC-DAD purity reports, heavy metal quantification via ICP-MS, and strict controls on microbial limits. Chenlv Herb ensures full documentation transparency to accelerate clearance in downstream supply lines.
Compliance with major regulatory frameworks like the US FDA, European Food Safety Authority (EFSA), and local National Health Commissions is standard practice. Our specialized compliance team assists with DMF (Drug Master Files) filings, CEP/COS validation applications, and issues custom COAs for every single export batch. We recognize that regulatory delays disrupt launches; thus, we offer extensive technical portfolios to support your local compliance filings from day one.
Chenlv Herb provides one-stop contract manufacturing services, converting research concepts into bulk industrial realities.
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Communicate with customers to determine product requirements and formulation objectives.
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Provide a detailed proposal and transparent pricing breakdown based on customer specifications.
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Establish legal and commercial frameworks to protect intellectual property and finalize batch specifications.
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Produce pilot scale samples in our analytical labs for efficacy and bioavailability testing.
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After customer approval of samples, the factory schedules and runs the commercial-scale order.
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Conduct quality control testing on batches and issue verified Certificates of Analysis (COAs).
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Coordinate international logistics to deliver finished products directly to your distribution centers.
Our operational procedures and products conform to international quality control systems, verified by regulatory bodies worldwide.
Pioneering scientific shifts defining the development of natural PCSK9 inhibitors, green extraction chemistry, and synergistic therapeutics.
The global cardiovascular health market is transitioning from synthetic monotherapies toward integrated therapeutics that utilize natural active ingredients. We are observing three core developments:
First, the emergence of Natural PCSK9 Inhibitors. Clinical interest has grown in natural products that decrease LDL receptor degradation, maintaining active clearance pathways. Second, Synergistic Formulations—such as combining Berberine Hydrochloride with bioflavonoids like Rutin or active agents like Silymarin—improve solubility and bioavailability in the small intestine. Lastly, the industry is prioritizing Green Extraction Chemistry. Global buyers are moving away from chlorinated extraction solvents toward safe, clean alternatives like water-ethanol processes and supercritical carbon dioxide extraction.
Chenlv Herb continues to invest in molecular separation technologies to keep our clients at the forefront of these industry changes. Our active compounds help brands design clean-label products that deliver measurable clinical efficacy.
Expert clarifications regarding botanical quality, shipping capabilities, and scientific extraction protocols.
Berberine Hydrochloride regulates cellular LDL cholesterol clearance by stabilizing LDL receptor (LDLR) mRNA expression through an extracellular signal-regulated kinase (ERK)-dependent pathway. Unlike statins, which restrict intracellular cholesterol synthesis, Berberine prolongs the active lifespan of hepatic receptors, boosting their ability to clear circulating LDL-c. It also helps downregulate PCSK9 protein levels to prevent receptor degradation.
Our facility uses automated ion-exchange chromatography and macroporous adsorption systems to capture target plant alkaloids while separating and removing contaminants. Every export batch is tested using ICP-MS and GC-MS/MS to ensure compliance with European Pharmacopoeia (EP) and United States Pharmacopeia (USP) thresholds.
We provide full documentation for global logistics, including high-performance liquid chromatography (HPLC) fingerprints, material safety data sheets (MSDS), non-irradiation certificates, non-GMO statements, BSE/TSE free declarations, and allergen breakdowns. We also offer DMF documentation for pharmaceutical-grade contracts.
Yes. Our particle engineering department can provide micro-milling services down to 80-200 mesh. We also supply customized granular forms, which are ideal for direct tableting, hard-gel capsule filling, or suspension formulas.
Stay updated on botanical ingredient market pricing, upcoming trade expos, and our latest extraction advances.
Recently, the market price of Citrus aurantium raw materials in China has been on the rise, drawing significant attention from the industry. As the new production season (May-June) comes to an end and new supplies gradually enter the market, price fluctuations have become a focal point due to supply and demand dynamics and cost considerations.
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As a 'calling card' for leading China's pharmaceutical industry onto the global stage, the 23rd China Pharmaceutical Raw Materials Exhibition (CPHI China 2025) will join hands with the 18th China Pharmaceutical Machinery, packaging, and raw material systems.
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Join Chengdu Chenlv Herb at the 92nd API conference as we explore the future of biotechnological isolation and clinical extract applications. We will be showcasing our latest high-purity active lines and customized client production services.
READ MORE →Premium functional compounds for targeted metabolic support, pharmaceutical synthesis, and dynamic animal health formulas.
