Explore our high-performance ingredients validated by international HPLC certification
In the rapidly evolving landscape of preventive medicine, longevity sciences, and functional wellness, the demand for purified phytochemical elements has reached an all-time high. Apigenin (4′,5,7-trihydroxyflavone), a natural bioflavonoid abundant in chamomile (Matricaria recutita), celery (Apium graveolens), and parsley, stands at the frontier of cellular optimization. As pharmaceutical and nutraceutical manufacturers across Germany, Austria, and Switzerland look to source bulk API-grade materials under strict European regulations, identifying a reliable supplier becomes critical to sustainable brand scaling.
Apigenin has transitioned from a basic herbal supplement to a core compound in longevity science. It is recognized as one of the most potent natural inhibitors of CD38, a cellular enzyme whose activity increases with age, depleting nicotinamide adenine dinucleotide (NAD+) levels. By down-regulating CD38, Apigenin aids in maintaining youthful NAD+ levels, which is crucial for mitochondrial health, DNA repair, and sirtuin activation. Furthermore, its ability to cross the blood-brain barrier (BBB) allows it to modulate GABA-A receptors, supporting stress-relief, neuroprotection, and sleep architecture without the dependency profile associated with synthetic alternatives.
From a formulation perspective, Apigenin exhibits low water solubility (approximately 1.35 µg/mL in water), making raw material processing, crystal form selection, and bioavailability enhancement techniques a priority. Industrial buyers look for reliable particle size distribution (micronization) or advanced delivery formulations (such as liposomal complexes) to bypass bioavailability barriers. This requires state-of-the-art phytochemistry engineering and stringent quality control protocols.
Acts as a targeted CD38 inhibitor, reversing age-related NAD+ degradation and supporting cellular vitality directly at the mitochondrial level.
Gently modulates benzodiazepine receptors to relieve oxidative stress, improve deep sleep cycles, and promote focus without daytime sleepiness.
Sourced and crystallized at high purities (98%+ by HPLC), ensuring zero pesticide residue, low heavy metals, and consistent batch-to-batch parameters.
Enterprise procurement departments in Germany and the wider European Union operate under strict regulatory and quality parameters. Sourcing bulk active materials from Chengdu Chenlv Herb ensures compliance with the highest standards of international phytochemistry. Our processes are designed to integrate seamlessly with standard EU supply chains, providing complete trace documentation, certification, and analytical validation.
Strict compliance with European regulations (EC No 1881/2006) for Lead (<3.0 ppm), Cadmium (<1.0 ppm), Mercury (<0.1 ppm), and Arsenic (<1.0 ppm).
Tested against GC-MS/MS and LC-MS/MS multi-residue screens matching the stringent European Pharmacopoeia (Ph. Eur. 2.8.13) rules.
Extraction processed using green solvents (ethanol and water). Residual ethanol kept strictly below USP <467> and Ph. Eur. standards.
Rigorous validation ensuring Aflatoxin B1, Ochratoxin A, and total aflatoxins stay below standard European regulatory thresholds.
Every shipment of Apigenin destined for the European market is accompanied by a comprehensive document package: a verified Certificate of Analysis (CoA) from accredited laboratories, Safety Data Sheets (SDS) matching REACH formats, a detailed allergen statement, BSE/TSE-Free declaration, Non-GMO verification, and technical processing flow charts. We facilitate customs clearance by providing clean HS classification codes and regulatory declarations.
Apigenin is not limited to a single form of application. As a versatile polyphenol, it serves multiple industrial sectors with tailored physical-chemical attributes. Chengdu Chenlv Herb develops customized solution paths for manufacturers in pharmaceuticals, health supplements, cosmetics, and animal nutrition.
Driven by the concept of "homology of medicine and food" and modern health needs, plant extracts have gradually become the core raw materials for the development of health care products due to their natural, green and safe characteristics.
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From herbal formulas recorded in ancient books to modern innovative drugs, plant extracts occupy the prominent position in the pharmaceutical industry due to their natural active ingredients and unique pharmacological effects.
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With consumers' pursuit of natural, safe, and sustainable skincare concepts, plant extracts have become a new favorite in the cosmetics industry due to their mildness, versatility, and biocompatibility, bringing new solutions for skin care.
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Plant extracts have shown great potential in improving animal health, enhancing production performance and optimizing culture benefits, and are gradually becoming a research hotspot and new favorite in the field of animal nutrition.
READ MOREOur research and development pipeline continues to innovate in bio-availability, synthesis pathways, and environment-friendly processing. We are building the next generation of botanical ingredient processing to keep our clients ahead of the competition.
As standard Apigenin is characterized by limited gut absorption, our R&D team is developing liposomal Apigenin formulations. By encapsulating active flavone molecules in a phospholipid bilayer, we increase gastrointestinal absorption kinetics by up to 5 times. Our technical pipeline also covers spray-drying-based micro-encapsulation techniques that mask taste and improve powder flowability for tablet compression and capsule filling.
Our sustainability commitment translates into a zero-waste manufacturing roadmap. We source our raw materials from sustainably managed crops and recycle plant fiber residues into natural bio-fertilizers. Looking forward, our green extraction process leverages subcritical water technologies and advanced membrane filtration to completely replace organic solvents, moving closer to a carbon-neutral production cycle.
Refining powder mesh sizes down to D90 < 10 microns to improve passive dissolution rates in dietary supplement capsules.
Launching liquid and powder liposomal systems for advanced absorption, optimized for ready-to-drink formulations and clean labels.
Co-developing enzyme-catalyzed conversions of naringenin into high-yield, high-sustainability bio-identical Apigenin.
Chengdu ChenLv Herb Co.,Ltd. (referred to as "Chenlv Herb") was established in 2012 as a high-tech enterprise specializing in the R&D, production, and sales of botanical extracts and natural pharmaceutical ingredients. Committed to providing high-purity, highly active, and premium-quality natural raw materials, the company serves diverse industries, including pharmaceuticals, health supplements, food, and cosmetics.
More than a decade of research, formulation validation, and compliance-driven global supply chain integrations.
Choose Chenlv Herb for products that deliver beyond expectations
Creative designs that elevate your brand.
Eco-friendly packaging aligned with today's values.
End-to-end cosmetic packaging solutions
Fast turnaround to meet your timelines.
A dedicated team supporting you every step of the way.
Years of expertise ensuring precision and excellence.
Chenlv Herb provides one-stop contract manufacturing services
Communicate with customers to determine product requirements
Provide a proposal quotation based on customer requirements
Sign a contract to further discuss the details of cooperation
Make samples
After customers confirm the samples, the factory schedules the production order
The factory tests the products and issues a certificate of analysis
Deliver finished products to customers
Our company is certified by ISO9001, ISO22000, HALAL, KOSHER and FDA etc.
Expert answers regarding chemical characteristics, logistics, regulatory compliance, and customized B2B formulations
Our standard industrial grade Apigenin is verified at ≥98% purity measured via High-Performance Liquid Chromatography (HPLC). We can provide customized assay requirements according to pharmaceutical or formulation specifications.
Every batch of our extracts is certified by third-party testing organizations (like SGS or Eurofins). We maintain strict limits in line with EU Regulation EC 396/2005 for pesticides and EC 1881/2006 for heavy metals, making our products fully eligible for import into Germany.
Generally, our commercial MOQ starts at 25kg (representing our standard drum packaging). However, for testing, validation, and pilot formulation trials, we can offer smaller evaluation samples (typically 1kg to 5kg) upon request.
Yes, to support our partners addressing bioavailability issues, we offer micronization services that can reduce the particle sizes down to D50 < 5 microns and D90 < 15 microns. This dramatically improves dissolution rates in formulation systems.
We have integrated research and development, manufacturing and sales together
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Consistent, high-efficiency formulation solutions for global bio-health businesses
