Explore our foundational range of premium plant-derived raw materials formulated for global pharmaceutical, cosmetic, and nutraceutical distribution.
Bridging natural extraction with target-specific clinical delivery mechanisms.
Apigenin (4',5,7-trihydroxyflavone) is an exceptionally potent, naturally occurring trihydroxyflavone that serves as a cornerstone in the formulation of cellular health, longevity, and anti-inflammatory therapeutics. Specifically extracted from high-yield cultivars such as Apium graveolens var. secalinum (known commercially as Varga Celery), Apigenin is characterized by its signature yellow crystalline structure. Varga-sourced apigenin contains elevated glycoside profiles which, when subjected to proprietary enzymolysis and multi-phase recrystallization techniques, yield highly bioavailable, pure Apigenin compounds suitable for advanced pharmaceutical integration.
In human pharmacology, Apigenin functions as a selective modulator of major intracellular pathways. It acts as an inhibitor of CD38, a primary NAD+-consuming enzyme, which subsequently elevates systemic NAD+ levels to mitigate cellular senescence. Additionally, its high affinity for GABA-A receptors underpins its widespread application in cognitive support and restorative sleep formulations. As a leading Custom Apigenin Varga Factory, Chengdu Chenlv Herb Co., Ltd. leverages refined extraction technologies to produce customizable purities ranging from 98% HPLC-standard active ingredients to tailored micro-powder suspensions.
Dedicated to pure botanical extraction and natural therapeutic active ingredient manufacturing.
Chengdu ChenLv Herb Co., Ltd. (referred to as "Chenlv Herb") was established in 2012 as a high-tech enterprise specializing in the R&D, production, and sales of botanical extracts and natural pharmaceutical ingredients. Committed to providing high-purity, highly active, and premium-quality natural raw materials, the company serves diverse industries, including pharmaceuticals, health supplements, food, and cosmetics.
Headquartered in Chengdu, Sichuan Province, Chenlv Herb operates a state-of-the-art cGMP-compliant manufacturing facility. We specialize in isolating high-value flavonoids, organic acids, and glycosides from verified botanical sources. Our commitment to sustainability, scientific precision, and strict batch-to-batch consistency has made us a trusted supplier to international pharmaceutical brands and global nutraceutical manufacturers.
Years of Natural Ingredients Production
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Company Personnel (Core PhD R&D)
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Choose Chenlv Herb for products that deliver beyond expectations
Creative designs and tailored chemical specifications that elevate your brand's market performance. We continually invest in novel recrystallization research to optimize the bioavailability of hydrophobic bioflavonoids.
Optimized eco-friendly packaging and continuous extraction processes aligned with modern clean-label values. Our high-throughput facility guarantees shorter lead times for large-scale industrial orders.
End-to-end green chemistry operations. We prioritize circular extraction solvents and zero-waste biomass disposal, offering verified, sustainable solutions that resonate with modern eco-conscious consumers.
Fast turnaround, comprehensive custom logistics support, and regulatory file preparation. Our dedicated technical account managers support client operations from lab trials to commercial production scale.
A specialized QA/QC team supervising every processing phase. Our in-house testing laboratory features HPLC, GC-MS, and ICP-MS capabilities to verify compliance with stringent pharmacopoeial standards.
Over a decade of industry expertise ensuring precision, compliance, and excellence. We translate botanical science into commercial success through reliable raw material consistency.
Innovating next-generation molecular delivery systems and synthetic biology pathways.
Apigenin's clinical application is frequently limited by its Class II status under the Biopharmaceutics Classification System (low solubility, high permeability). Our R&D department is pioneering micro-precipitation, lipid-based nano-emulsions, and cyclodextrin-complexation processes. These methods significantly accelerate dissolution rates and oral bioavailability, paving the way for lower dosing requirements in final consumer formulations.
While organic extraction from Apium graveolens var. secalinum remains the industry standard for clean-label supplements, our future roadmap includes metabolic engineering projects. By researching microbial yeast fermentation pipelines for de novo synthesis of apigenin, we aim to offer a highly scalable alternative that minimizes agricultural dependency, land footprint, and crop vulnerability.
Aligning with carbon-neutral industrial directives, we are shifting our solvent systems to bio-sourced, food-grade ethanol and water-recycling extraction chambers. The application of continuous supercritical CO2 systems is currently under verification to bypass traditional solvent recovery processes, ensuring that our Apigenin retains a clean, green environmental footprint from harvest to delivery.
Custom botanical active formats tailored for diverse global manufacturing sectors.
Driven by the concept of "homology of medicine and food" and modern health needs, plant extracts have gradually become the core raw materials for the development of health care products due to their natural, green and safe characteristics. We supply high-density Apigenin powders optimized for capsules and compressed tablets.
From herbal formulas recorded in ancient books to modern innovative drugs, plant extracts occupy the prominent position in the pharmaceutical industry due to their natural active ingredients and unique pharmacological effects. Our API-grade Apigenin features strictly verified impurity profiles and complete regulatory support.
With consumers' pursuit of natural, safe, and sustainable skincare concepts, plant extracts have become a new favorite in the cosmetics industry due to their mildness, versatility, and biocompatibility, bringing new solutions for skin care. We offer micronized Apigenin for anti-aging creams and topical protective serums.
Plant extracts have shown great potential in improving animal health, enhancing production performance and optimizing culture benefits, and are gradually becoming a research hotspot and new favorite in the field of animal nutrition. Our veterinary-grade flavonoids promote gut health and immunity naturally.
Combining industrial scale with digital manufacturing controls for predictable deliveries.
Our Chengdu facility operates under a digital Factory 4.0 network, integrating manufacturing execution systems (MES) with real-time HPLC process chromatography tracking. Every extraction batch is monitored from biomass drying to crystallizer temperature profiling. This eliminates manual batch variations and prevents compound denaturation during processing.
By using high-throughput countercurrent extractors and automated multi-stage concentration evaporators, we minimize water use and optimize solvent recycling. This level of process optimization lowers overall cost barriers while scaling production up to metric tons without compromising purity.
Global logistics and agricultural supply chains face regular climatic and economic disruptions. To protect our partners from stock shortages, Chenlv Herb maintains raw agricultural supply networks spanning multiple geographic regions within China. Additionally, we keep safe stock inventory buffers of both unrefined crude materials and packaged pure Apigenin within climate-controlled warehouses.
This multi-node supply framework, coupled with local agent clearance agreements in key markets, guarantees consistent batch delivery even during standard seasonal transitions or shipping delays.
Chenlv Herb provides one-stop contract manufacturing services.
Initial consult with customer teams to outline customized purity, particle distribution, and intended product applications.
We supply detailed wholesale quotes and contract manufacturing cost structures based on target volume and compliance standards.
Finalizing legal terms, regulatory documentation delivery schedules, and quality assurance criteria.
R&D laboratory pilots custom sample batches (e.g., custom mesh sizes or liposomal formulations) for client verification.
After customer sample approval, the production line schedules high-volume manufacturing campaigns.
The quality control laboratory tests the batch against predefined guidelines and issues a Certificate of Analysis (COA).
Finished goods are packed securely and dispatched via ocean, air, or express global freight.
Ensuring compliance across diverse global markets.
We support global entry by providing complete regulatory documentation, including US FDA DMF filings, European CEP dossiers, and comprehensive raw material safety data sheets (SDS) complying with GHS standards.
Navigating phytosanitary and border protection requirements can slow shipping timelines. Our compliance division handles all customs documentation, heavy metal certificates, and pesticide residue declarations for smooth clearances.
For strategic high-volume clients, we support dedicated local warehousing options in destination countries. This mitigates overseas delays and enables quick dispatch of emergency manufacturing batches.
Our company is certified by ISO9001, ISO22000, HALAL, KOSHER and FDA etc.
Chengdu Chenlv Herb integrates research and development, manufacturing, and sales together.
Recently, the market price of Citrus aurantium raw materials in China has been on the rise, drawing significant attention from the industry. As the new production season comes to an end and new supplies enter the market, price fluctuations have become a focal point due to supply dynamics and cost considerations.
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As a key industry event showcasing Chinese pharmaceuticals on the global stage, the 23rd CPHI China 2025 will join hands with the 18th China Pharmaceutical Machinery Exhibition to drive technical innovation and global sales opportunities.
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We are excited to share our latest research breakthroughs in natural ingredient crystallization and standard reference development. Connect with our technical experts on-site to explore custom apigenin opportunities.
READ MORE →Expert answers regarding crystallization, bioavailability, customization, and batch compliance.
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